Our development version of WordShell now has a feature that’s in-demand: support for multi-site (a.k.a. WordPress network – think of wordpress.com) installations. You can now activate, de-activate and list activation status for plugins either network-wide, or on an individual blog. (Installing, upgrading and removing plugins is already supported on multi-site, since these operations are the same as on an ordinary install).
The online manual is already up-to-date with this new feature, so take a look there to get the flavour.